02 Reproduction in Lower and Higher Animals - part 17 - Infertility
02 Reproduction in Lower and Higher Animals - part 17 - Infertility
Infertility :
- Infertility is defined as the inability to conceive naturally after (one year of) regular unprotected intercourse.
- The causes of infertility could be physical, congenital, diseases, immunological or even psychological.
- The common physical causes in females are -
- polycystic ovary syndrome (PCOS)
- hormonal imbalance
- endometriosis
- while in male, it is -
- less sperm count and
- small size of penis.
- prior to 1978, infertile couple had two options, adopt or be childless.
- Today infertile couples have many options to have a child such as -
- fertility drugs
- test tube babies
- artificial insemination
- IUI
- surrogate motherhood, etc.
- The couple could be assisted to have child / children through certain special techniques commonly known as Assisted Reproductive Technologies (ART).
IVF (In Vitro Fertization) :
- It is a process of fertization where an egg is combined with sperm outside the body in a test tube or glass plate to form a zygote under simulated conditions in the laboratory.
- The zygote or early embryos (with up to 8 blastomeres) could be then transferred into the fallopian tube for further development.
ZIFT (Zygote Intrafallopian Transfer) :
- ZIFT is an infertility treatment used when there is a blockage in the fallopian tubes which prevents the fertilization of egg by the sperm.
- In this method, egg is removed from woman's ovary.
- Fertilization of the egg with sperms is brought about outside the body under sterile conditions to form zygote by the process called in vitro fertilization (IVF).
- The zygote is then transferred to fallopian tube for further development.
GIFT (Gamete Intrafallopian Transfer) :
- Transfer of an ovum collected from a donor into the fallopian tube of another female who can provide suitable environment for its fertilization and development. This technique called gamete intrafallopian transfer (GIFT)
- GIFT has been developed for the cases in which only the entrance to the oviducts or the upper segment of the oviducts in blocked.
- In this procedure ova and sperms are directly injected into regions of the oviduct, where fertilization produces a blastocyst, which enters the uterus via the normal route.
- GIFT has a success rate of about 30 percent.
ICSI (Intra Cytoplasmic Sperm Injection) :
- ICSI is an in vitro fertilization procedure in which a single sperm cell is injected directly into cytoplasm of an ovum in the laboratory.
- Here the sperm has to naturally penetrate the egg.
Artificial Insemination (AI) :
- In some infertility cases, the male partner is unable to inseminate the female due to a very low sperm count.
- This problem can be solved by artificial insemination.
- In this technique, the sperms are collected from the male and artificially introduced into the cervix of female, for the purpose of achieving a pregnancy through in vivo fertilization (inside the body).
IUI (Intra Uterine Insemination) :
- In this technique the process is somewhat like that of artificial insemination, the only difference is that the sperms are introduced into the uterine cavity instead of cervix.
Sperm bank / Semen bank:
- A sperm bank or semen bank is a place which collects, stores and provides human sperms / semen.
- The semen is provided by healthy males called sperm donors.
- The sperms are stored in sperm bank by cryo preservation method (at low temperature).
Surrogate mother :
- Some women have problem in implantation of embryo in uterus.
- Such woman can take help of the modern remedial technique called surrogacy.
- In this, embryo is implanted in surrogate mother, who is not the biological mother.
Adoption :
- Adoption is a legal process by which a couple or a single parent gets legal rights, privileges and responsibilities that are associated to a biological child for the upbringing of the adopted child.
- An adoptive parent should be medically fit and financially able to take care of the adopted child.
- A person wishing to adopt a child must be at least 21 years old but there is no legal upper age limit for adoption.
Always Remember :
- Tobacco, marijuana and other drugs smoking may cause infertility in both men and women.
- Nicotine blocks the production of sperm and decreases the size of testicles.
- Alcoholism by men interferes with the synthesis of testosterone and has an impact on sperm count.
- Use of cocaine or marijuana may temporarily reduce the number and quality of sperm.
Always Remember :
- Cells of trophoblast do not form any part of the embryo proper.
- They form ectoderm of the chorion (extra embryonic membrane).
- They play important role in formation of placenta.
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